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Psychedelics Alcohol and Drug Foundation Pretreatment of the trained rats with PCP, an NMDA antagonist, dramatically shifted the dose-response curve leftward. When a dose of 0.1 mg/kg DOM was administered, rats emitted only 32% DOM-appropriate responding. Yet when combined with a range of doses of the noncompetitive NMDA antagonists PCP, dizocilpine, or ketamine, DOM-appropriate lever selection was increased to 73%, 84%, and 79%, respectively. Consistent with other studies, the data show that the stimulus effects of phenethylamine hallucinogens are potentiated by pretreatment with noncompetitive NMDA antagonists. Common experiences include flashing lights, flashing colors, seeing halos around people, and severe emotional distress. People can also experience very vivid and frightening hallucinations as they are totally unexpected. Even though individuals appear to develop some level of tolerance to LSD, there is no significant literature describing withdrawal symptoms; thus, there is...